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In vitro In vivo correlation of sustained release capsules of Metoprolol

Author(s): Kannan.K | Manavalan.R | Karar.P.K

Journal: Journal of Pharmaceutical Sciences and Research
ISSN 0975-1459

Volume: 2;
Issue: 9;
Start page: 562;
Date: 2010;
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In vitro in vivo correlation of metoprolol tartrate sustained release capsules were studied in this investigation. The half-life of metoprolol is 3 to 4 hours. Peak plasma concentrations vary widely and occur about 1.5 to 2 hours after a single oral dose. In this study, non pareil seeds were prepared and coated with metoprolol tartrate using polyvinyl pyrollidone and iso propyl alcohol. Drug coated pellets were then coated with different proportion of microcrystalline wax and glyceryl di stearate using carbon tetrachloride as solvent. The release pattern of drug coated pellets and wax coated pellets were evaluated in vitro by dissolution test apparatus. Theoretical sustained release was compared with formulated sustained release. In vivo evaluation of metoprolol sustained release has been studied. Asingle dose was carried out in six rabbits with two sequences, cross over study. Blood samples were collected at one hour intervals. The plasma concentration of metoprolol was estimated by reverse phase HPLC. The pharmacokinetic parameters were calculated from the plasma concentration of metoprolol and time data. The mean in vitro dissolution curve of the product is compared with the mean in vivo absorption curve generated by Wagner – Nelson method. The mean data for the in vivo percent absorbed were plotted versus time and the in vitro drug release versus time were superimposed on the first plot. The simplest way to demonstrate a correlation is to plot the percentage absorbed in vivo versus the percentage released in vitro at the same time.

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