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In vivo and in vitro Studies of Kinetic Changes of Serum, Liver and Brain High and Low Molecular Weight Alkaline Phosphatase Following Aluminium Exposure in Rat

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Author(s): Seyyed Mehdi Mirhashemi | Ali-Asghar Moshtaghie | Mohsen Ani | Mohammad-Hossein Aarabi

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 5;
Issue: 1;
Start page: 1;
Date: 2010;
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Keywords: high molecular weight alkaline phosphatase | alkaline phosphatase | Aluminium | liver | brain

ABSTRACT
1 000 000) and a low molecular mass form (Mr: 150000). The relationship between aluminium treatment and changes in the activity of serum, liver and brain high and low molecular weight alkaline phosphatase has been investigated in this manuscript. Results obtained from in vivo study showed that every other day intrapritoneally injection of 186 mol kg-1 of aluminium (AlCl3.6H2O), in male rats for 2 weeks resulted in decreasing the level of liver and brain alkaline phosphatase by 14.9 and 9.9%, respectively, whereas an elevation of serum levels of this enzyme by 21.1% was seen in comparison to untreated controls (p
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