Author(s): Bapu R Thorata, Dyneshwar Shelke, Ramdas Atram and Ramesh Yamgar
Journal: Heterocyclic Letters
ISSN 2231-3087
Volume: 3;
Issue: 3;
Start page: 385;
Date: 2013;
Original page
Keywords: Vanillin | Mannich reaction | Intramolecular Wittig reaction | acid chloride.
ABSTRACT
Vanillin undergoes sequence of reaction forming phosphonium salt through dimethyaminomethyl derivative (Mannich reaction). The synthesis of phosphonium salt can be achieved by sequence of three steps which was condense with series of aliphatic/aromatic acid chlorides by refluxing in toluene in presence of triethylamine (Wittig reaction) as key step resulting 7-methoxy-2-alkyl/aryl-l-benzofuran-5-carboxaldehyde. The crude product was purified by using column chromatography and characterized by FTIR, NMR and Mass spectroscopy.
Journal: Heterocyclic Letters
ISSN 2231-3087
Volume: 3;
Issue: 3;
Start page: 385;
Date: 2013;
Original page
Keywords: Vanillin | Mannich reaction | Intramolecular Wittig reaction | acid chloride.
ABSTRACT
Vanillin undergoes sequence of reaction forming phosphonium salt through dimethyaminomethyl derivative (Mannich reaction). The synthesis of phosphonium salt can be achieved by sequence of three steps which was condense with series of aliphatic/aromatic acid chlorides by refluxing in toluene in presence of triethylamine (Wittig reaction) as key step resulting 7-methoxy-2-alkyl/aryl-l-benzofuran-5-carboxaldehyde. The crude product was purified by using column chromatography and characterized by FTIR, NMR and Mass spectroscopy.
