In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Author(s): Lynn A. Hyde | Qi Zhang | Robert A. Del Vecchio | Prescott T. Leach | Mary E. Cohen-Williams | Lei Chen | Gwendolyn T. Wong | Nansie A. McHugh | Joseph Chen | Guy A. Higgins | Theodros Asberom | Wei Li | Dmitri Pissarnitski | Diane Levitan | Amin A. Nomeir | John W. Clader | Lili Zhang | Eric M. Parker
Volume: 2013
Year: 2013

Longitudinal Changes in the Government-Certified Index Stage and Requisite Costs for Long-Term Care Insurance System among the Community-Dwelling Demented Elderly in Japan

Author(s): Shunichiro Shinagawa | Shiori Nakamura | Makoto Iwamoto | Norifumi Tsuno | Masahiro Shigeta | Kazuhiko Nakayama
Volume: 2013
Year: 2013

γ-Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?

Author(s): Jeremy H. Toyn | Adele Rowley | Yasuji Matsuoka | Taisuke Tomita | Bruno P. Imbimbo
Volume: 2013
Year: 2013

Care for Alzheimer's Disease

Author(s): Hiroyuki Umegaki | Hajime Takechi | Hiroko H. Dodge
Volume: 2013
Year: 2013

Virtual Screening and Biological Evaluation of Piperazine Derivatives as Human Acetylcholinesterase Inhibitors

Author(s): Kavitha Raj Varadaraju | Jajur Ramanna Kumar | Lingappa Mallesha | Archana Muruli | Kikkeri Narasimha Shetty Mohana | Chethan Kumar Mukunda | Umesha Sharanaiah
Volume: 2013
Year: 2013

Role of Copper and Cholesterol Association in the Neurodegenerative Process

Author(s): Nathalie Arnal | Gustavo R. Morel | María J. T. de Alaniz | Omar Castillo | Carlos A. Marra
Volume: 2013
Year: 2013

Effects of Copper and/or Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration

Author(s): Nathalie Arnal | Omar Castillo | María J. T. de Alaniz | Carlos A. Marra
Volume: 2013
Year: 2013

Neuroprotective Role of a Novel Copper Chelator against Induced Neurotoxicity

Author(s): Sandeep Kumar Singh | Priti Sinha | L. Mishra | S. Srikrishna
Volume: 2013
Year: 2013

Biomarkers in Alzheimer's Disease and Lewy Body Disorders with Dementia

Author(s): Thomas Leyhe | Taher Darreh-Shori | Christoph Laske | Michelle M. Mielke | Walter Maetzler
Volume: 2013
Year: 2013

Acetylcholinesterase Inhibitors Promote Angiogenesis in Chick Chorioallantoic Membrane and Inhibit Apoptosis of Endothelial Cells

Author(s): Seyed Mohsen Mortazavian | Heydar Parsaee | Seyed Hadi Mousavi | Zahra Tayarani-Najaran | Ahmad Ghorbani | Hamid Reza Sadeghnia
Volume: 2013
Year: 2013

Broader Considerations of Higher Doses of Donepezil in the Treatment of Mild, Moderate, and Severe Alzheimer's Disease

Author(s): Camryn Berk | Marwan Sabbagh
Volume: 2012
Year: 2012

The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes: A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?

Author(s): Daniel A. Bórquez | Christian González-Billault
Volume: 2012
Year: 2012

Mild Cognitive Impairment: Statistical Models of Transition Using Longitudinal Clinical Data

Author(s): Erin L. Abner | Richard J. Kryscio | Gregory E. Cooper | David W. Fardo | Gregory A. Jicha | Marta S. Mendiondo | Peter T. Nelson | Charles D. Smith | Linda J. Van Eldik | Lijie Wan | Frederick A. Schmitt
Volume: 2012
Year: 2012

Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

Author(s): Thomas Kramer | Boris Schmidt | Fabio Lo Monte
Volume: 2012
Year: 2012

Tau Phosphorylation by GSK3 in Different Conditions

Author(s): Jesús Avila | Gonzalo León-Espinosa | Esther García | Vega García-Escudero | Félix Hernández | Javier DeFelipe
Volume: 2012
Year: 2012

Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes: A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology

Author(s): Anna Poggesi | Emilia Salvadori | Leonardo Pantoni | Giovanni Pracucci | Francesca Cesari | Alberto Chiti | Laura Ciolli | Mirco Cosottini | Alessandra Del Bene | Nicola De Stefano | Stefano Diciotti | Maria Teresa Dotti | Andrea Ginestroni | Betti Giusti | Anna Maria Gori | Serena Nannucci | Giovanni Orlandi | Francesca Pescini | Raffaella Valenti | Rosanna Abbate | Antonio Federico | Mario Mascalchi | Luigi Murri | Domenico Inzitari
Volume: 2012
Year: 2012

Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β: A Protective Role of Melatonin

Author(s): Sergio A. Rosales-Corral | Gabriela Lopez-Armas | Jose Cruz-Ramos | Valery G. Melnikov | Dun-Xian Tan | Lucien C. Manchester | Ruben Munoz | Russel J. Reiter
Volume: 2012
Year: 2012

Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action

Author(s): Amala Soumyanath | Yong-Ping Zhong | Edward Henson | Teri Wadsworth | James Bishop | Bruce G. Gold | Joseph F. Quinn
Volume: 2012
Year: 2012

Vaccine Development to Treat Alzheimer’s Disease Neuropathology in APP/PS1 Transgenic Mice

Author(s): Iván Carrera | Ignacio Etcheverría | Lucía Fernández-Novoa | Valter Lombardi | Ramón Cacabelos | Carmen Vigo
Volume: 2012
Year: 2012

Microglia in Alzheimer Brain: A Neuropathological Perspective

Author(s): Robert E. Mrak
Volume: 2012
Year: 2012

The Effects of SIRT1 on Alzheimer's Disease Models

Author(s): Gizem Donmez
Volume: 2012
Year: 2012

A Two-Study Comparison of Clinical and MRI Markers of Transition from Mild Cognitive Impairment to Alzheimer’s Disease

Author(s): D. P. Devanand | Xinhua Liu | Patrick J. Brown | Edward D. Huey | Yaakov Stern | Gregory H. Pelton
Volume: 2012
Year: 2012

Caspase-Mediated Truncation of Tau Potentiates Aggregation

Author(s): Sangmook Lee | Thomas B. Shea
Volume: 2012
Year: 2012

Alzheimer's Disease and the Amyloid Cascade Hypothesis: A Critical Review

Author(s): Christiane Reitz
Volume: 2012
Year: 2012

Executive Dysfunction in MCI: Subtype or Early Symptom

Author(s): Ivar Reinvang | Ramune Grambaite | Thomas Espeseth
Volume: 2012
Year: 2012

Relative Preservation of Advanced Activities in Daily Living among Patients with Mild-to-Moderate Dementia in the Community and Overview of Support Provided by Family Caregivers

Author(s): Hajime Takechi | Atsuko Kokuryu | Tomoko Kubota | Hiroko Yamada
Volume: 2012
Year: 2012

Analyzing Microarray Data of Alzheimer's Using Cluster Analysis to Identify the Biomarker Genes

Author(s): Satya vani Guttula | Apparao Allam | R. Sridhar Gumpeny
Volume: 2012
Year: 2012

A Warning Index Used in Prescreening for Alzheimer’s Disease, Based on Self-Reported Cognitive Deficits and Vascular Risk Factors for Dementia in Elderly Patients with Type 2 Diabetes

Author(s): Toshioki Matsuzawa | Toshihiro Takata | Koichi Yokono | Hiroo Ueda | Kensuke Moriwaki | Isao Kamae | Katsuya Urakami | Takashi Sakurai
Volume: 2012
Year: 2012

Specific EEG Changes Associated with Atrophy of Hippocampus in Subjects with Mild Cognitive Impairment and Alzheimer's Disease

Author(s): D. V. Moretti | A. Prestia | C. Fracassi | G. Binetti | O. Zanetti | G. B. Frisoni
Volume: 2012
Year: 2012

The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid

Author(s): Teresa A. Ellis | Jinhe Li | David LeBlond | Jeffrey F. Waring
Volume: 2012
Year: 2012

The Impact of Experience with a Family Member with Alzheimer’s Disease on Views about the Disease across Five Countries

Author(s): Robert J. Blendon | John M. Benson | Elizabeth M. Wikler | Kathleen J. Weldon | Jean Georges | Matthew Baumgart | Beth A. Kallmyer
Volume: 2012
Year: 2012

-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid -Protein Production

Author(s): Mako Takami | Satoru Funamoto
Volume: 2012
Year: 2012

Promising Genetic Biomarkers of Preclinical Alzheimer's Disease: The Influence of APOE and TOMM40 on Brain Integrity

Author(s): Beata Ferencz | Sari Karlsson | Grégoria Kalpouzos
Volume: 2012
Year: 2012

Amyloid Beta and Tau Proteins as Therapeutic Targets for Alzheimer’s Disease Treatment: Rethinking the Current Strategy

Author(s): Siddhartha Mondragón-Rodríguez | George Perry | Xiongwei Zhu | Jannic Boehm
Volume: 2012
Year: 2012

Characterizing Cognitive Deficits and Dementia in an Aging Urban Population in India

Author(s): G. Nair | K. Van Dyk | U. Shah | D. P. Purohit | C. Pinto | A. B. Shah | H. Grossman | D. Perl | V. Ganwir | S. Shanker | M. Sano
Volume: 2012
Year: 2012

Florbetaben PET in the Early Diagnosis of Alzheimer's Disease: A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps

Author(s): Shien Guo | Denis Getsios | Luis Hernandez | Kelly Cho | Elizabeth Lawler | Arman Altincatal | Stephan Lanes | Michael Blankenburg
Volume: 2012
Year: 2012

Sweepers in the CNS: Microglial Migration and Phagocytosis in the Alzheimer Disease Pathogenesis

Author(s): Mariko Noda | Akio Suzumura
Volume: 2012
Year: 2012

Alternative Strategy for Alzheimer’s Disease: Stress Response Triggers

Author(s): Joan Smith Sonneborn
Volume: 2012
Year: 2012

The Alzheimer's Amyloid-Degrading Peptidase, Neprilysin: Can We Control It?

Author(s): N. N. Nalivaeva | N. D. Belyaev | I. A. Zhuravin | A. J. Turner
Volume: 2012
Year: 2012

Hormone Replacement Therapy and Risk for Neurodegenerative Diseases

Author(s): Richelin V. Dye | Karen J. Miller | Elyse J. Singer | Andrew J. Levine
Volume: 2012
Year: 2012

Automated VOI Analysis in FDDNP PET Using Structural Warping: Validation through Classification of Alzheimer's Disease Patients

Author(s): Moses Q. Wilks | Hillary Protas | Mirwais Wardak | Vladimir Kepe | Gary W. Small | Jorge R. Barrio | Sung-Cheng Huang
Volume: 2012
Year: 2012

Trends in Prevalence and Mortality of Dementia in Elderly Hong Kong Population: Projections, Disease Burden, and Implications for Long-Term Care

Author(s): Ruby Yu | Pui Hing Chau | Sarah M. McGhee | Wai Ling Cheung | Kam Che Chan | Sai Hei Cheung | Jean Woo
Volume: 2012
Year: 2012

Ocular Manifestations of Alzheimer’s Disease in Animal Models

Author(s): Miles Parnell | Li Guo | Mohamed Abdi | M. Francesca Cordeiro
Volume: 2012
Year: 2012

Efficacy of Music Therapy in Treatment for the Patients with Alzheimer’s Disease

Author(s): H. Fukui | A. Arai | K. Toyoshima
Volume: 2012
Year: 2012

Chinese-Language Montreal Cognitive Assessment for Cantonese or Mandarin Speakers: Age, Education, and Gender Effects

Author(s): Ling Zheng | Evelyn L. Teng | Rohit Varma | Wendy J. Mack | Dan Mungas | Po H. Lu | Helena C. Chui
Volume: 2012
Year: 2012

The Contribution of the Amyloid Hypothesis to the Understanding of Alzheimer's Disease: A Critical Overview

Author(s): Laura Morelli | George Perry | Fabrizio Tagliavini
Volume: 2012
Year: 2012

Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology

Author(s): Kristen E. Funk | Jeff Kuret
Volume: 2012
Year: 2012

Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress

Author(s): Puchchakayala Goverdhan | Akina Sravanthi | Thati Mamatha
Volume: 2012
Year: 2012

Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer’s Disease

Author(s): Izumi Maezawa | David Paul Jenkins | Benjamin E. Jin | Heike Wulff
Volume: 2012
Year: 2012

-Secretase Modulators: Can We Combine Potency with Safety?

Author(s): Harrie J. M. Gijsen | Marc Mercken
Volume: 2012
Year: 2012